Neural Plasticity

Neural Plasticity refers to the ability of a neural circuit to be shaped by experience. It happens all the time.

There is:

  • Short time plasticity: acts on a timescale of milliseconds to minutes.
    • Synaptic facilitation: strengthening of synaptic connections.
    • Synaptic depression
  • Long time plasticity: acts on a timescale of hours or more.
    • Long-term potentiation (LTP)
      • More neurotransmitters released
      • Increase number of receptors post synaptic
      • Make the postsynaptic receptors produce a larger effect
      • Hebbian or non-Hebbian
        • Non-hebbian
          • anti-hebbian-ltp, synapse weaks whe together
        • NMDAReceptor is hebbian
    • Long-term depression (LTD)
      • Hippocampus
        • related to glutamate
        • persistent weak synaptic stimulation
      • cerebellum
        • strong synaptic stimulation
  • Hebb’s Rule: cells that fire together, wire together. Neurons out of sync, lose their link.
  • Associative Learning:
  • Spike timing dependent plasticity
  • Non-synaptic plasticity: not locally restricted to synapses. emerging field. modifications of ion channels.